Differences in ischemia-reperfusion-induced endothelial changes in hearts perfused at constant flow and constant pressure

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Differences in ischemia-reperfusion-induced endothelial changes in hearts perfused at constant flow and constant pressure.

Isolated hearts subjected to ischemia-reperfusion (I/R) exhibit depressed cardiac performance and alterations in subcellular function. Since hearts perfused at constant flow (CF) and constant pressure (CP) show differences in their contractile response to I/R, this study was undertaken to examine mechanisms responsible for these I/R-induced alterations in CF-perfused and CP-perfused hearts. Rat...

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Low-flow ischemia and hypoxia stimulate apoptosis in perfused hearts independently of reperfusion.

Post-ischemic reperfusion leads to apoptosis-linked loss of myocytes in cultured cells and in vivo. We tested the hypothesis that apoptosis develops without reperfusion in Langendorff-perfused hearts exposed to either low-flow ischemia (LFI) or hypoxia (H). Rat hearts were perfused with amino-acid-enriched Krebs-Henseleit buffer and exposed for 6 h to LFI (flow=2 ml/min, PO(2)=500+/-50mmHg, mea...

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Effects of Constant Flow vs. Constant Pressure Perfusion on Fluid Filtration in Severe Hypothermic Isolated Blood-Perfused Rat Lungs

BACKGROUND Victims of severe accidental hypothermia are prone to fluid extravasation but rarely develop lung edema. We hypothesize that combined hypothermia-induced increase in pulmonary vascular resistance (PVR) and a concomitant fall in cardiac output protect the lungs against edema development. Our aim was to explore in hypothermic-isolated blood-perfused rat lungs whether perfusion at const...

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Effect of endogenous nitric oxide on cardiac ischemic preconditioning in rat

Introduction: Ischemic Preconditioning (IPC) is the phenomen that happens on the heart by one or several short periods of ischemia followed by reperfusion that improve the postischemic recovery of mechanical function. Ischemic preconditioning (IPC) may protect the heart from ischemia reperfusion injury by nitric oxide formation. This study investigated the effect of ischemic preconditioni...

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ژورنال

عنوان ژورنال: Journal of Applied Physiology

سال: 2008

ISSN: 8750-7587,1522-1601

DOI: 10.1152/japplphysiol.00076.2008